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Why our exosome so pure?
Answer: By targeted filtration, our filter of specific binding treatment removes protein contaminant to isolate exosome at 95% high purity.        Click to see pure exosome images
101Bio Cat.# Product Name Application
101Bio P100 Exosome isolation - Cell cell media exosome
101Bio P101 Exosome isolation - Serum serum/plasma exosome
101Bio P101NGS Serum/Plasma Exosome NGS Kit serum/plasma exosome RNA for NGS
101Bio P107 Exosome isolation - Stem Cell stem cell media exosome
101Bio P120 Exosome isolation - Urine urine exosome
101Bio P121 Exosome isolation - BodyFluid body fluid exosome
101Bio P130 Exosome-TEM-easy Kit exosome TEM imaging
101Bio P140 Human Exosomes, purified from normal human serum
101Bio P141 Cancer / Disease Exosomes, purified from patient serum     New!
101Bio P200 Exosomal RNA / Protein extraction exosome RNA/Protein
101Bio P200RExosomal RNA Extraction Kit exosome RNA
101Bio P200PExosomal Protein Lysis Buffer exosome Protein
101Bio P201Detergent-free Exosomal Protein Extraction exosome Detergent-free Protein
101Bio P230 Exosomal DNA extraction exosome DNA
101Bio P240 Normal Exosomal RNA (NGS ready, 500 ng)     New! exosome RNA
NGS ready
101Bio P241 Cancer Exosomal RNA (NGS ready, 500 ng)     New! exosome RNA
NGS ready
101Bio P300 Exo Protein - Serum/plasma serum/plasma Exosomal Protein
101Bio P400 Exosome Electroporation small RNA into
 exosome
101Bio P401 Exosome Transfection small RNA into
 exosome
101Bio P402 Exosome Transfection Plasmid DNA into
 exosome
101Bio S100Exosome Isolation Services, Normal /Disease Disease exosome (RNA) extracted from patients
101Bio P528 Endosome Isolation Kit Cells/Tissues Endosome
101Bio P530 Saliva Exosome Isolation Kit Saliva exosome

Our filtration exosome isolation method optimize your exosome research result

Exosome Isolation Kits, exosome purification, Exosomal RNA and Protein Extraction kit
Our kits have gained satisfaction from our customers from

NIH, Harvard, Stanford, Sigma, Qiagen, Johns Hopkins, UCSF, UCLA, MD Anderson and Cornell, etc.

Vendor 101Bio.com Competitor 1 Competitor 2
Isolated Exosome Purity High at 95% Low Low
Yield of Exosome 10 x 1 x 1 x
Small RNA Transfectable Yes No No
Good size distribution of exosomes isolated by our PureExo kit
   (See larger screen click: exosome purification method, exosome isolation method)

Nanoparticle tracking analysis shows good size distribution, morphology and amount of exosome isolated by 101bio PureExo kit.

101Bio  Citations
PureExo® Exosome Isolation kit (for cell culture media)     Cat.#: P100  Link
Citation 1:
Osteikoetxea X, Németh A, Sódar BW, Vukman KV, Buzás EI. Extracellular vesicles in cardiovascular diseases, are they Jedi or Sith?
J Physiol. 2016 Feb 13. doi: 10.1113/JP271336   
Citation 2:
Korbelik M, Banáth J, Zhang W, Wong F, Bielawski J, Separovic D. Ceramide and Sphingosine-1-Phosphate/Sphingosine act as Photodynamic Therapy-Elicited Damage-Associated Molecular Patterns: Release from Cells and Impact on Tumor-Associated Macrophages. J Anal Bioanal Tech. S1:009. doi: 10.4172/2155-9872.S1-009 (2014)  
Citation 3:
Salama A, Fichou N, Allard M, Dubreil L, De Beaurepaire L, Viel A, Jégou D, Bösch S, Bach JM. MicroRNA-29b modulates innate and antigen-specific immune responses in mouse models of autoimmunity. PLoS One. 2014 Sep 9;9(9):e106153. doi: 10.1371/journal.pone.0106153.  (Sold through our European distributor - Gentaur.)
Citation 4:
Marędziak M, Marycz K, Lewandowski D, Siudzińska A, Śmieszek A. Static magnetic field enhances synthesis and secretion of membrane-derived microvesicles (MVs) rich in VEGF and BMP-2 in equine adipose-derived stromal cells (EqASCs)-a new approach in veterinary regenerative medicine. In Vitro Cell Dev Biol Anim. 2015 Mar;51(3):230-40. doi: 10.1007/s11626-014-9828-0.  
Citation 5:
Tomoyo Kawakubo-Yasukochi, Masahiko Morioka, Yoshikazu Hayashi, Takuya Nishinakagawa, Mai Hazekawa, Shintaro Kawano, Seiji Nakamura, Manabu Nakashima    The SQUU-B cell line spreads its metastatic properties to nonmetastatic clone SQUU-A from the same patient through exosomes. J of Oral Biosciences   2015/09
PureExo® citation from Japan distributor Cosmo indicates interesting exosome function: "exosome derived from highly metastatic SQUU-B cells conferred metastatic ability to nonmetastatic SQUU-A cells."
Citation 6:
William G. Whitford    Exosomes: A Major Phenomenon Flying Under the Radar cellculturedish.com   2015/09
Citation 7:
Bonafede R, Scambi I, Peroni D, Potrich V, Boschi F, Benati D, Bonetti B, Mariotti R.    Exosome derived from murine adipose-derived stromal cells: Neuroprotective effect on in vitro model of amyotrophic lateral sclerosis. Exp Cell Res.   2016 Jan 1;340(1):150-8. doi: 10.1016/j.yexcr.2015.12.009. Epub 2015 Dec 18.
Citation 8:
Zhou Y, Fang L, Yu Y, Niu J, Jiang L, Cao H, Sun Q, Zen K, Dai C, Yang J.    Erythropoietin protects the tubular basement membrane by promoting the bone marrow to release extracellular vesicles containing tPA-targeting miR-144. Am J Physiol Renal Physiol.   2016 Jan 1;310(1):F27-40. doi: 10.1152/ajprenal.00303.2015. Epub 2015 Oct 14.
Citation 9:
Campbell CR, Berman AE, Weintraub NL, Tang YL.    Electrical stimulation to optimize cardioprotective exosomes from cardiac stem cells. Med Hypotheses.   2016 Mar;88:6-9. doi: 10.1016/j.mehy.2015.12.022. Epub 2016 Jan 11.
Citation 10:
Zhu D, Liu Z, Wang F. Effect of exosome extracted from 3T3 on proliferation of mouse colorectal cancer cells CT26. Chin J of Exp Surg. 2015 July;32(7):1634-36
Citation 11:
Rager T, Olson J, Zhou Y, Wang Y, Besner G. Exosomes Secreted from Bone Marrow-Derived Mesenchymal Stem Cells Protect the Intestines from Experimental Necrotizing Enterocolitis. J Pediatr Surg. 2016 March;S0022-3468(16)00149-4
Citation 12:
Li X, Liu L, Yang J, Yu Y, Chai J, Wang L, Ma L, Yin H. Exosome Derived From Human Umbilical Cord Mesenchymal Stem Cell Mediates MiR-181c Attenuating Burn-induced Excessive Inflammation. EBioMedicine. 2016, http://dx.doi.org/10.1016/j.ebiom.2016.04.030
Citation 13:
Masahiko Moriokaa, Tomoyo Kawakubo-Yasukochia, Yoshikazu Hayashi, Mai Hazekawa, Takuya Nishinakagawa, Kazuhiko Ono, Shintaro Kawano, Seiji Nakamura, Manabu Nakashima. Exosomes from oral squamous carcinoma cell lines, SQUU-A and SQUU-B, define the tropism of lymphatic dissemination. J of Oral Biosciences. 2016, http://dx.doi.org/10.1016/j.job.2016.05.001i
Citation 14:
Kiyoshi Takahara, Masaaki Ii, Teruo Inamoto, Takatoshi Nakagawa, Naokazu Ibuki, Yuki Yoshikawa, Takuya Tsujino, Taizo Uchimoto, Kenkichi Saito, Tomoaki Takai, Naoki Tanda, Koichiro Minami, Hirofumi Uehara, Kazumasa Komura, Hajime Hirano, Hayahito Nomi, Satoshi Kiyama, Michio Asahi, and Haruhito Azuma. microRNA-145 Mediates the Inhibitory Effect of Adipose Tissue-Derived Stromal Cells on Prostate Cancer. Stem Cells Dev. 2016 Sep 1;25(17):1290-8. doi: 10.1089/scd.2016.0093. Epub 2016 Aug 18.
Citation 15:
Alice Busato, Roberta Bonafede, Pietro Bontempi, Ilaria Scambi, Lorenzo Schiaffino, Donatella Benati, Manuela Malatesta, Andrea Sbarbati, Pasquina Marzola, and Raffaella Mariotti. Magnetic resonance imaging of ultrasmall superparamagnetic iron oxide-labeled exosomes from stem cells: a new method to obtain labeled exosomes. Int J Nanomedicine. 2016; 11: 2481–2490.
Citation 16:
Li Chen and David R. Brigstock. Integrins and heparan sulfate proteoglycans on hepatic stellate cells (HSC) are novel receptors for HSC-derived exosomes. FEBS Lett. 2016 Dec;590(23):4263-4274. doi: 10.1002/1873-3468.12448. Epub 2016 Oct 23.
Citation 17:
Donald G. Phinney and Mark F. Pittenger Concise Review: MSC-Derived Exosomes for Cell-Free Therapy. Stem Cells. 2017 Apr;35(4):851-858. doi: 10.1002/stem.2575. Epub 2017 Mar 10.
PureExo® Exosome Isolation kit (for serum or plasma)     Cat.#: P101  Link
Citation 1:
Chen L, Chen R, Kemper S, Charrier A, Brigstock DR. Suppression of fibrogenic signaling in hepatic stellate cells by Twist1-dependent microRNA-214 expression: Role of exosomes in horizontal transfer of Twist1. Am J Physiol Gastrointest Liver Physiol. 2015 Sep 15;309(6):G491-9. doi: 10.1152/ajpgi.00140.2015. Epub 2015 Jul 30.  
This paper is awarded TOP 10 best original research papers published by the American Physiological Society (APS Select). Link
(APSselect is a collection of the very best original research papers published by the American Physiological Society. Each month, the most outstanding recently published papers from our ten research journals are selected and made available through this multi-journal website.)
Citation 2:
Osteikoetxea X, Németh A, Sódar BW, Vukman KV, Buzás EI. Extracellular vesicles in cardiovascular diseases, are they Jedi or Sith?
J Physiol. 2016 Feb 13. doi: 10.1113/JP271336   
Citation 3:
William G. Whitford    Exosomes: A Major Phenomenon Flying Under the Radar cellculturedish.com   2015/09
Citation 4:
Chen L., Chen R., Brigstock D. MicroRNA profiling of circulating exosomes during experimental liver fibrosis. Hepatology. AASLD abstract, 2014 Oct. (Presidential Honored Distinct Abstract).  
Citation 5:
Li Chen and David R. Brigstock. Cellular or Exosomal microRNAs Associated with CCN Gene Expression in Liver Fibrosis. CCN Proteins. Volume 1489 of the series Methods in Molecular Biology pp 465-480.  
Citation 6:
Kayo Nakamura, Masatoshi Jinnin*, Miho Harada, Hideo Kudo, Wakana Nakayama, Kuniko Inoue, Aki Ogata, Ikko Kajihara, Satoshi Fukushima, Hironobu Ihn. Altered expression of CD63 and exosomes in scleroderma dermal fibroblasts. J Dermatol Sci.2016 Oct;84(1):30-39. doi: 10.1016/j.jdermsci.2016.06.013. Epub 2016 Jul 1.  
Citation 7:
Li Chen and David R. Brigstock. Integrins and heparan sulfate proteoglycans on hepatic stellate cells (HSC) are novel receptors for HSC-derived exosomes. FEBS Lett. 2016 Dec;590(23):4263-4274. doi: 10.1002/1873-3468.12448. Epub 2016 Oct 23.
Citation 8:
Yan Sun, Sha Liu, Zhi Qiao, Zhi Shang, Zhijun Xia, Xiaomin Niu, Liqiang Qian, Yan Zhang, Liuyin Fan, Cheng-Xi Cao, Hua Xiao. Systematic comparison of exosomal proteomes from human saliva and serum for the detection of lung cancer. Anal Chim Acta. 2017 Aug 22;982:84-95. doi: 10.1016/j.aca.2017.06.005. Epub 2017 Jun 17.
Exosome-TEM-easy Kit     Cat.#: P130  Link
Citation 1:
Heedoo Lee, Duo Zhang, Ziwen Zhu , Charles S. Dela Cruz, Yang Jin. Epithelial cell-derived microvesicles activate macrophages and promote inflammation via microvesicle-containing microRNAs. Sci Rep. 2016 Oct 12;6:35250. doi: 10.1038/srep35250.
Citation 2:
Abu Musa Md Talimur Reza, Yun-Jung Choi, Hideyo Yasuda, and Jin-Hoi Kim. Human adipose mesenchymal stem cell-derived exosomal-miRNAs are critical factors for inducing anti-proliferation signalling to A2780 and SKOV-3 ovarian cancer cells. Sci Rep. 2016 Dec 8;6:38498. doi: 10.1038/srep38498.
Citation 3:
Duo Zhang, Heedoo Lee, Ziwen Zhu, Jasleen K Minhas and Yang Jin. Enrichment of selective miRNAs in exosomes and delivery of exosomal miRNAs in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol. 2017 Jan 1;312(1):L110-L121. doi: 10.1152/ajplung.00423.2016. Epub 2016 Nov 23.
Exosomal RNA and Protein Extraction Kit     Cat.#: P200  Link
Citation 1:
Li X, Liu L, Yang J, Yu Y, Chai J, Wang L, Ma L, Yin H. Exosome Derived From Human Umbilical Cord Mesenchymal Stem Cell Mediates MiR-181c Attenuating Burn-induced Excessive Inflammation. EBioMedicine. 2016, http://dx.doi.org/10.1016/j.ebiom.2016.04.030
ExoFectin® sRNA-into-Exosome Kit (Chemical)     Cat.#: P401  Link
Citation 1:
Salama A, Fichou N, Allard M, Dubreil L, De Beaurepaire L, Viel A, Jégou D, Bösch S, Bach JM. MicroRNA-29b modulates innate and antigen-specific immune responses in mouse models of autoimmunity. PLoS One. 2014 Sep 9;9(9):e106153. doi: 10.1371/journal.pone.0106153.  (Sold through our European distributor Gentaur.)
ExoFectin® sRNA-into-Exosome Kit (Electro)     Cat.#: P400  Link
Citation 1:
MARTINEZ N., SAITTA S., PATACQ C. Utilisation d’exosomes comme bithérapie contre le cancer du colon . Projet de recherche 2013-2014.
Plasma Membrane Protein Extraction Kit (mammalian cells or tissues)     Cat.#: P503  Link
Citation 1:
Shibata T, Takahashi K, Matsubara Y, Inuzuka E, Nakashima F, Takahashi N, Kozai D, Mori Y, Uchida K. Identification of a prostaglandin D2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel. Sci Rep. 2016 Feb 16;6:21261. doi: 10.1038/srep21261.   
Citation 2:
Ramsey J, Renzi EC, Arnold RJ, Trinidad JC, Mukhopadhyay S. Palmitoylation of Sindbis Virus TF Protein Regulates Its Plasma Membrane Localization and Subsequent Incorporation into Virions. J Virol. 2017 Jan 18;91(3). pii: e02000-16. doi: 10.1128/JVI.02000-16. Print 2017 Feb 1.   
Citation 3:
Ishigaki H, Maeda T, Inoue H, Akagi T, Sasamura T, Ishida H, Inubushi T, Okahara J, Shiina T, Nakayama M, Itoh Y, Ogasawara K. Transplantation of iPS-Derived Tumor Cells with a Homozygous MHC Haplotype Induces GRP94 Antibody Production in MHC-Matched Macaques. Cancer Res. 2017 Nov 1;77(21):6001-6010. doi: 10.1158/0008-5472.CAN-17-0775. Epub 2017 Sep 7.    
8-min. Cytoplasmic & Nuclear Protein Extraction Kit (cells & tissues)     Cat.#: P504  Link
Citation 1:
Frismantiene A, Dasen B, Pfaff D, Erne P, Resink TJ, Philippova M. T-cadherin promotes vascular smooth muscle cell dedifferentiation via a GSK3β-inactivation dependent mechanism. Cell Signal. 2016 Feb 22;28(5):516-530. doi: 10.1016/j.cellsig.2016.02.014.   
Citation 2:
Matsumura K, Nakazawa T, Nagayasu K, Gotoda-Nishimura N, Kasai A, Hayata-Takano A, Shintani N, Yamamori H, Yasuda Y, Hashimoto R, Hashimoto H. De novo POGZ mutations in sporadic autism disrupt the DNA-binding activity of POGZ. J Mol Psychiatry. 2016 Apr 21;4:1. doi: 10.1186/s40303-016-0016-x. eCollection 2016.
Citation 3:
Koichi Inouea, Eisuke Sakuma, Hiroyuki Morimoto, Hayato Asai, Yoshinori Koide, Tiandong Leng, Ikuo Wada, Zhi-Gang Xiong, Takatoshi Ueki. Serum- and glucocorticoid-inducible kinases in microglia. Biochem Biophys Res Commun. 2016 Sep 9;478(1):53-9. doi: 10.1016/j.bbrc.2016.07.094. Epub 2016 Jul 22.
8-min. Plant Tissue Total Protein Extraction Kit     Cat.#: P508  Link
Citation 1:
Xianjun Peng, Qi Wang, Hui Liu,Shihua Shen. Phylogenetic and functional analysis of the basic transcription factor gene BTF3 from Jatropha curcas. Plant Growth Regul. June 2017, Volume 82, Issue 2, pp 247–257.
3D Cell Culture Gel - Col-Tgel     Cat.#: P720  Link
Citation 1:
Kuwahara, Kenrick, Zhi Yang, Ginger C. Slack, Marcel E. Nimni and Bo Han. Cell delivery using an injectable and adhesive transglutaminase–gelatin gel. Tissue Engineering Part C: Methods 16, no. 4 (2009): 609-618.
Citation 2:
Kuwahara, Kenrick, Josephine Y. Fang, Zhi Yang and Bo Han. Enzymatic crosslinking and degradation of gelatin as a switch for bone morphogenetic protein-2 activity. Tissue Engineering Part A 17, no. 23-24 (2011): 2955-2964.
Citation 3:
Fang, Josephine, Zhi Yang, ShihJye Tan, Charisse Tayag, Marcel E. Nimni, Mark Urata and Bo Han. Injectable gel graft for bone defect repair. Regenerative medicine 9, no. 1 (2014): 41-51.
Citation 4:
Tan, ShihJye, Josephine Y. Fang, Zhi Yang, Marcel E. Nimni and Bo Han. The synergetic effect of hydrogel stiffness and growth factor on osteogenic differentiation. Biomaterials 35, no. 20 (2014): 5294-5306.
Citation 5:
Fang, Josephine Y., Shih-Jye Tan, Zhi Yang, Charisse Tayag and Bo Han. Tumor Bioengineering Using a Transglutaminase Crosslinked Hydrogel. PloS one 9, no. 8 (2014): e105616.
Citation 6:
Shih-Jye Tan, Fang, Josephine Y., Y. Wu, Zhi Yang, G. Liang and Bo Han. Muscle tissue engineering and regeneration through epigenetic reprogramming and scaffold manipulation. Sci Rep. 2015 Nov 9;5:16333. doi: 10.1038/srep16333.   
Citation 7:
Lee G, Kim HJ, Kim HM. RhoA-JNK Regulates the E-Cadherin Junctions of Human Gingival Epithelial Cells. J Dent Res. 2015 Dec 3. pii: 0022034515619375. [Epub ahead of print]
Citation 8:
Fang JY, Tan SJ, Wu YC, Yang Z, Hoang BX, Han B. From competency to dormancy: a 3D model to study cancer cells and drug responsiveness. J Transl Med. 2016 Feb 4;14(1):38. doi: 10.1186/s12967-016-0798-8.